Functional Human CD141+ Dendritic Cells in Human Immune System Mice
نویسندگان
چکیده
منابع مشابه
Constitutive resistance to viral infection in human CD141+ dendritic cells.
Dendritic cells (DCs) are critical for the launching of protective T cell immunity in response to viral infection. Viruses can directly infect DCs, thereby compromising their viability and suppressing their ability to activate immune responses. How DC function is maintained in light of this paradox is not understood. By analyzing the susceptibility of primary human DC subsets to viral infection...
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Two subsets of conventional dendritic cells (cDCs) with distinct cell surface markers and functions exist in mouse and human. The two subsets of cDCs are specialized antigen-presenting cells that initiate T cell immunity and tolerance. In the mouse, a migratory cDC precursor (pre-CDC) originates from defined progenitors in the bone marrow (BM). Small numbers of short-lived pre-CDCs travel throu...
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Muzlifah Haniffa,1,2 Amanda Shin,2,10 Venetia Bigley,1,10 Naomi McGovern,1 Pearline Teo,2 Peter See,2 Pavandip Singh Wasan,2 Xiao-Nong Wang,1 Frano Malinarich,2 Benoit Malleret,2 Anis Larbi,2 Pearlie Tan,3 Helen Zhao,2 Michael Poidinger,2 Sarah Pagan,1 Sharon Cookson,1 Rachel Dickinson,1 Ian Dimmick,1 Ruth F. Jarrett,4 Laurent Renia,2 John Tam,5,6 Colin Song,3 John Connolly,2 Jerry K.Y. Chan,6,...
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Human immune cell subsets develop in immunodeficient mice following reconstitution with human CD34+ hematopoietic stem cells. These "humanized" mice are useful models to study human immunology and human-tropic infections, autoimmunity, and cancer. However, some human immune cell subsets are unable to fully develop or acquire full functional capacity due to a lack of cross-reactivity of many gro...
متن کاملHuman CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines.
Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuat...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2019
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jiz432